effect of plasma membrane cholesterol depletion on glucose transport regulation in leukemia cells质膜胆固醇耗竭的影响在白血病细胞葡萄糖运输监管.pdfVIP

Effect of Plasma Membrane Cholesterol Depletion on Glucose Transport Regulation in Leukemia Cells Cristiana Caliceti, Laura Zambonin, Cecilia Prata, Francesco Vieceli Dalla Sega, Gabriele Hakim, Silvana Hrelia, Diana Fiorentini* Biochemistry Department ‘‘G. Moruzzi’’, Alma Mater Studiorum-University of Bologna, Bologna, Italy Abstract GLUT1 is the predominant glucose transporter in leukemia cells, and the modulation of glucose transport activity by cytokines, oncogenes or metabolic stresses is essential for their survival and pro