effect of oxidative stress on homer scaffolding proteins氧化应激对荷马脚手架蛋白的影响.pdfVIP

Effect of Oxidative Stress on Homer Scaffolding Proteins Igor Nepliouev, Zhu-Shan Zhang, Jonathan A. Stiber* Ion Channel Research Unit and Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America Abstract Homer proteins are a family of multifaceted scaffolding proteins that participate in the organization of signaling complexes at the post-synaptic density and in a variety of tissues including striated muscle. Homer isoforms form multimers via their C- terminal coiled coil domains, which allows for the formation of a po