functional foveal splitting evidence from neuropsychological and multimodal mri investigations in a chinese patient with a splenium lesion功能性视网膜中央凹分裂来自神经心理学的证据和多通道mri调查在中国压部病变的病人.pdfVIP

Functional Foveal Splitting: Evidence from Neuropsychological and Multimodal MRI Investigations in a Chinese Patient with a Splenium Lesion 1 2 3 4,5 6 Benyan Luo , Chunlei Shan *, Renjing Zhu , Xuchu Weng , Sheng He 1 Department of Neurology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China, 2 Department of Rehabilitation Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 3 Department of Neurology, Zhongshan Hospital, Xiamen University, Xiamen, China, 4 Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China, 5 The Center for Human Brain Research, Hangzhou Normal University, Hangzhou, China, 6 Department of Psychology, University of Minnesota, Minneapolis, Minnesota, United States of America Abstract It remains controversial and hotly debated whether foveal information is double-projected to both hemispheres or split at the midline between the two hemispheres. We investigated this issue in a unique patient with lesions in the splenium of the corpus callosum and the left medial occipitotemporal region, through a series of neuropsychological tests and multimodal MRI scans. Behavioral experiments showed that (1) the patient had difficulties in reading simple and compound Chinese characters when they were presented in the foveal but left to the fixation, (2) he failed to recognize the left component of compound characters when the compound characters were presented in the central foveal field, (3) his judgments of the gender of centrally presented chimeric faces were exclusively based on the left half-face and he was unaware that the faces were chimeric. Functional MRI data showed that Chinese characters, only when presented in the right foveal field but