原创力文档genetic and environmental factors influencing the placental growth factor (pgf) variation in two populations遗传和环境因素影响胎盘生长因子(pgf)两个种群的变化.pdfVIP
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genetic and environmental factors influencing the placental growth factor (pgf) variation in two populations遗传和环境因素影响胎盘生长因子(pgf)两个种群的变化
Genetic and Environmental Factors Influencing the
Placental Growth Factor (PGF) Variation in Two
Populations
1 1 1 1 2
Rossella Sorice , Daniela Ruggiero , Teresa Nutile , Mario Aversano , Lotte Husemoen ,
2 3 4 1
Allan Linneberg , Catherine Bourgain , Anne-Louise Leutenegger , Marina Ciullo *
1 Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Naples, Italy, 2 Research Centre for Prevention and Health, Glostrup, Denmark, 3 Inserm/University Paris
SUD U669, Villejuif, France, 4 INSERM, U946, Paris, France
Abstract
Placental Growth Factor (PGF) is a key molecule in angiogenesis. Several studies have revealed an important role of PGF
primarily in pathological conditions (e.g.: ischaemia, tumour formation, cardiovascular diseases and inflammatory processes)
suggesting its use as a potential therapeutic agent. However, to date, no information is available regarding the genetics of
PGF variability. Furthermore, even though the effect of environmental factors (e.g.: cigarette smoking) on angiogenesis has
been explored, no data on the influence of these factors on PGF levels have been reported so far. Here we have first
investigated PGF variability in two cohorts focusing on non-genetic risk factors: a study sample from two isolated villages in
the Cilento region, South Italy (N = 871) and a replication sample from the general Danish population (N = 1,812). A
significant difference in PGF mean levels was found between the two cohorts. However, in both samples, we observed a
strong correlation of PGF levels with ageing and sex, men displaying PGF levels significantly highe
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