genetic and epigenetic somatic alterations in head and neck squamous cell carcinomas are globally coordinated but not locally targeted遗传和表观遗传的改变在头颈部鳞状细胞癌是全球协调但不是本地的目标.pdfVIP

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genetic and epigenetic somatic alterations in head and neck squamous cell carcinomas are globally coordinated but not locally targeted遗传和表观遗传的改变在头颈部鳞状细胞癌是全球协调但不是本地的目标.pdf

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genetic and epigenetic somatic alterations in head and neck squamous cell carcinomas are globally coordinated but not locally targeted遗传和表观遗传的改变在头颈部鳞状细胞癌是全球协调但不是本地的目标

Genetic and Epigenetic Somatic Alterations in Head and Neck Squamous Cell Carcinomas Are Globally Coordinated but Not Locally Targeted 1 2,3 3,4 5 Graham M. Poage , Brock C. Christensen , E. Andres Houseman , Michael D. McClean , John K. 6 7 8 9 2 1,2,3 Wiencke , Marshall R. Posner , John R. Clark , Heather H. Nelson , Carmen J. Marsit , Karl T. Kelsey * 1 Departments of Molecular Pharmacology and Physiology, Brown University, Providence, Rhode Island, United States of America, 2 Departments of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America, 3 Department of Community Health, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island, United States of America, 4 Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America, 5 Department of Environmental Health, Boston University, Boston, Massachusetts, United States of America, 6 Department of Neurological Surgery, University of California San Francisco, San Francisco, California, United States of America, 7 Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, 8 Department of Medicine Hematology/Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, 9 Division of Epidemiology and Community Health, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America Abstract Backgro