genetic interactions between the drosophila tumor suppressor gene ept and the stat92e transcription factor基因之间的相互作用的果蝇肿瘤抑制基因ept和stat92e转录因子.pdfVIP
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genetic interactions between the drosophila tumor suppressor gene ept and the stat92e transcription factor基因之间的相互作用的果蝇肿瘤抑制基因ept和stat92e转录因子
Genetic Interactions between the Drosophila Tumor
Suppressor Gene ept and the stat92E Transcription
Factor
M. Melissa Gilbert, Carolyn K. Beam, Brian S. Robinson, Kenneth H. Moberg*
Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, United States of America
Abstract
Background: Tumor Susceptibility Gene-101 (TSG101) promotes the endocytic degradation of transmembrane proteins and
is implicated as a mutational target in cancer, yet the effect of TSG101 loss on cell proliferation in vertebrates is uncertain. By
contrast, Drosophila epithelial tissues lacking the TSG101 ortholog erupted (ept) develop as enlarged undifferentiated
tumors, indicating that the gene can have anti-growth properties in a simple metazoan. A full understanding of pathways
deregulated by loss of Drosophila ept will aid in understanding potential links between mammalian TSG101 and growth
control.
Principal Findings: We have taken a genetic approach to the identification of pathways required for excess growth of
Drosophila eye-antennal imaginal discs lacking ept. We find that this phenotype is very sensitive to the genetic dose of
stat92E, the transcriptional effector of the Jak-Stat signaling pathway, and that this pathway undergoes strong activation in
ept mutant cells. Genetic evidence indicates that stat92E contributes to cell cycle deregulation and excess cell size
phenotypes that are observed among ept mutant cells. In addition, autonomous Stat92E hyper-activation is associated with
altered tissue architecture in ept tumors and an effect on expression of the apical polarity determinant crumbs.
Conclusions: These findings identify ept as a cell-autonomous inhibitor of the Jak-Stat pathway and suggest that excess Jak-
Stat signaling makes a significant contribution to proli
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