genetic liability to disability pension in women and men a prospective population-based twin study遗传残疾退休金责任在女性和男性潜在人群双胞胎研究.pdfVIP

Genetic Liability to Disability Pension in Women and Men: A Prospective Population-Based Twin Study 1 2 3 1 4,5,6 Jurgita Narusyte *, Annina Ropponen , Karri Silventoinen , Kristina Alexanderson , Jaakko Kaprio , ˚ 1, Pia Svedberg1 Asa Samuelsson 1 Division of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, 2 Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland, 3 Population Research Unit, Department of Social Research, University of Helsinki, Helsinki, Finland, 4 Department of Public Health, University of Helsinki, Helsinki, Finland, 5 Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland, 6 Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland Abstract Background: Previous studies of risk factors for disability pension (DP) have mainly focused on psychosocial, or environmental, factors, while the relative importance of genetic effects has been less studied. Sex differences in biological mechanisms have not been investigated at all. Methods: The study sample included 46,454 Swedish twins, consisting of 23,227 complete twin pairs, born 1928–1958, who were followed during 1993–2008. Data on DP, including diagnoses, were obtained from the National Social Insurance Agency. Within-pair similarity in liability to DP was assessed by calculating intraclass correlations. Genetic and environmental influences on liability to DP were estimated by applying discrete-time frailty modeling. Results: During follow-u