genome-wide linkage analysis of malaria infection intensity and mild disease全基因组关联分析疟疾感染强度和轻微的疾病.pdfVIP

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genome-wide linkage analysis of malaria infection intensity and mild disease全基因组关联分析疟疾感染强度和轻微的疾病.pdf

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genome-wide linkage analysis of malaria infection intensity and mild disease全基因组关联分析疟疾感染强度和轻微的疾病

Genome-Wide Linkage Analysis of Malaria Infection Intensity and Mild Disease 1,2* 1,3 ¨ 2 ´ 2 ¨ 4 1 Christian Timmann , Jennifer A. Evans , Inke R. Konig , Andre Kleensang , Franz Ruschendorf , Julia Lenzen , ¨ 1 4,5 3 3 3 Jurgen Sievertsen , Christian Becker , Yeetey Enuameh , Kingsley Osei Kwakye , Ernest Opoku , Edmund N. L. Browne6 2 ¨ 4,5 1 , Andreas Ziegler , Peter Nurnberg , Rolf D. Horstmann 1 Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany, 2 Institute of Medical Biometry and Statistics, University Hospital ¨ ¨ ¨ Schleswig-Holstein, Campus Lubeck, University at Lubeck, Lubeck, Germany, 3 Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana, 4 Max ¨ Delbruck Centre for Molecular Medicine, Berlin, Germany, 5 Cologne Center for Genomics, University of Cologne, Cologne, Germany, 6 Department of Community Health, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana Although balancing selection with the sickle-cell trait and other red blood cell disorders has emphasized the interaction between malaria and human genetics, no systematic approach has so far been undertaken towards a comprehensive search for human genome variants influencing malaria. By screening 2,551 families in rural Ghana, West Africa, 108 nuclear families were identified who were exposed to hyperendemic malaria transmission and were homozygou