histidine protects against zinc and nickel toxicity in caenorhabditis elegans组氨酸在秀丽隐杆线虫防止锌和镍的毒性.pdfVIP

下载本文档

1
0
约 12页
2017-09-01 发布于上海
举报
版权申诉

histidine protects against zinc and nickel toxicity in caenorhabditis elegans组氨酸在秀丽隐杆线虫防止锌和镍的毒性.pdf

1、本文档共12页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

histidine protects against zinc and nickel toxicity in caenorhabditis elegans组氨酸在秀丽隐杆线虫防止锌和镍的毒性

Histidine Protects Against Zinc and Nickel Toxicity in Caenorhabditis elegans 1 1¤ 1 1 2 John T. Murphy , Janelle J. Bruinsma , Daniel L. Schneider , Sara Collier , James Guthrie , Asif 3 2,4 3 1 Chinwalla , J. David Robertson , Elaine R. Mardis , Kerry Kornfeld * 1 Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America, 2 Research Reactor Center, University of Missouri, Columbia, Missouri, United States of America, 3 The Genome Center, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America, 4 Department of Chemistry, University of Missouri, Columbia, Missouri, United States of America Abstract Zinc is an essential trace element involved in a wide range of biological processes and human diseases. Zinc excess is deleterious, and animals require mechanisms to protect against zinc toxicity. To identify genes that modulate zinc tolerance, we performed a forward genetic screen for Caenorhabditis elegans mutants that were resistant to zinc toxicity. Here we demonstrate that mutations of the C. elegans histidine ammonia lyase (haly-1) gene promote zinc tolerance. C. elegans haly- 1 encodes a protein that is homologous to vertebrate HAL, an enzyme that converts histidine to urocanic acid. haly-1 mutant animals displayed elevated levels of histidine, indicating that C. elegans HALY-1 protein is an enzyme involved in histidine catabolism. These results suggest the model that elevated histidine chelates zinc and thereby reduces zinc toxicity. Supporting