nontypeable haemophilus influenzae genetic islands associated with chronic pulmonary infectionnontypeable流感嗜血杆菌基因岛与慢性肺部感染有关.pdfVIP

Nontypeable Haemophilus influenzae Genetic Islands Associated with Chronic Pulmonary Infection 1 1 2 2 3,4 3 Lixin Zhang *, Jingping Xie , Mayuri Patel , Arsala Bakhtyar , Garth D. Ehrlich , Azad Ahmed , 3 1 5 6 1,2 Josh Earl , Carl F. Marrs , Daniel Clemans , Timothy F. Murphy , Janet R. Gilsdorf 1 Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America, 2 Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, 3 Center for Genomic Sciences, Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania, United States of America, 4 Departments of Microbiology and Immunology, and Otolaryngology Head and Neck Surgery, Drexel University College of Medicine, Pittsburgh, Pennsylvania, United States of America, 5 Department of Biology, Eastern Michigan University, Ypsilanti, Michigan, United States of America, 6 Division of Infectious Diseases, Department of Medicine, Department of Microbiology, New York State Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, State University of New York, Buffalo, New York, United States of America Abstract Background: Haemophilus influenzae (Hi) colonizes the human respiratory tract and is an important pathogen associated with chronic obstructive pulmonary disease (COPD). Bacterial factors that interact with the human host may be important in the pathogenesis of COPD. These factors, however, have not been well defined. The overall goal of this study was to identi