obesity risk gene tmem18 encodes a sequence-specific dna-binding protein肥胖风险编码sequence-specific tmem18基因dna结合蛋白质.pdfVIP

Obesity Risk Gene TMEM18 Encodes a Sequence-Specific DNA-Binding Protein Jaana M. Jurvansuu*, Adrian Goldman Structural Biology and Biophysics, Institute of Biotechnology, University of Helsinki, Helsinki, Finland Abstract Transmembrane protein 18 (TMEM18) has previously been connected to cell migration and obesity. However, the molecular function of the protein has not yet been described. Here we show that TMEM18 localises to the nuclear membrane and binds to DNA in a sequence-specific manner. The protein binds DNA with its positively charged C-terminus that contai