scutellaria baicalensis extracts and flavonoids protect rat l6 cells from antimycin a-induced mitochondrial dysfunction黄芩提取物和类黄酮保护大鼠16种细胞抗霉素a-induced线粒体功能障碍.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 517965, 8 pages doi:10.1155/2012/517965 Research Article Scutellaria baicalensis Extracts and Flavonoids Protect Rat L6 Cells from Antimycin A-Induced Mitochondrial Dysfunction A-Rang Im,1 Young-Hwa Kim,1 Md. Romij Uddin,1, 2 Hye Won Lee,1 Seong Wook Chae,1 Yun Hee Kim,1 Woo Suk Jung,1 Bong Ju Kang,1 Chun Sun Mun,3 and Mi-Young Lee1 1 Korea Institute of Oriental Medicine, 461-24 Jeonmin-dong, Yuseong-gu, Daejeon 305-811, Republic of Korea 2 Department of Crop Science, Chungnam National University, Daejeon 305-764, Republic of Korea 3 School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China Correspondence should be addressed to Mi-Young Lee, mylee@kiom.re.kr Received 11 June 2012; Revised 20 July 2012; Accepted 23 July 2012 Academic Editor: Vassya Bankova Copyright © 2012 A-Rang Im et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Antimycin A (AMA) damages mitochondria by inhibiting mitochondrial electron transport and can produce reactive oxygen species (ROS). ROS formation, aging, and reduction of mitochondrial biogenesis contribute to mitochondrial dysfunction. The present study sought to investigate extracts of Scutellaria baicalensis and its flavonoids (baicalin, baicalein, and wogonin), whether they could protect mitochondria against oxidative damage. The viability of L6 cells treated with AMA increased in the presence of flavonoids and extracts of S. baicalensis. ATP production decreased in the AMA treated group, but increased by 50% in cells treated w