on propagation of excitation waves in moving media the fitzhugh-nagumo model在移动媒体fitzhugh-nagumo激发波的传播模型.pdfVIP

On Propagation of Excitation Waves in Moving Media: The FitzHugh-Nagumo Model 1 2,3 4,5 6 7 Elena A. Ermakova , Emmanuil E. Shnol , Mikhail A. Panteleev , Andrey A. Butylin , Vitaly Volpert , Fazoil I. Ataullakhanov4,5,6* 1 Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia, 2 Institute of Mathematical Problems of Biology, Russian Academy of Sciences, Pushchino, Moscow Region, Russia, 3 Pushchino State University, Pushchino, Moscow Region, Russia, 4 National Research Center for Hematology, Russian Academy of Medical Sciences, Moscow, Russia, 5 Center for Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences, Moscow, Russia, 6 Department of Physics, Moscow State University, Moscow, Russia, 7 Institute of Mathematics, UMR 5208 CNRS, Universite Lyon 1, Villeurbanne, France Abstract Background: Existence of flows and convection is an essential and integral feature of many excitable media with wave propagation modes, such as blood coagulation or bioreactors. Methods/Results: Here, propagation of two-dimensional waves is studied in parabolic channel flow of excitable medium of the FitzHugh-Nagumo type. Even if the stream velocity is hundreds of times higher that the wave velocity in motionless medium (w), steady propagation of an excitation wave is eventually established. At high stream velocities, the wave does not span the channel from wall to wall, forming isolated excited regions, which we called ‘‘restrictons’’. They are especially easy to observe when the model parameters are close to critical ones, at which waves disappear in still medium. In the subcritical region of parameters, a sufficiently fast stream can result in the surviv