shengjie tongyu granule inhibits vascular remodeling in apoe-gene-knockout mice在apoe-gene-knockout老鼠shengjie通榆颗粒抑制血管重建.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 897875, 13 pages doi:10.1155/2012/897875 Research Article Shengjie Tongyu Granule Inhibits Vascular Remodeling in ApoE-Gene-Knockout Mice Min Chen,1, 2 Wenli Cheng,1 Zaixiang Shi,1 Nishihara Tatsukazu,1, 2 Tongliang Zhou,3 Hong Li,3 and Jian Guo3 1 Center for Cardiovascular Diseases, China-Japan Friendship Hospital, Ministry of Health, Beijing 100029, China 2 Graduate School, Beijing University of Traditional Chinese Medicine, Beijing 100029, China 3 Instutite of Clinical Studies, China-Japan Friendship Hospital, Ministry of Health, Beijing 100029, China Correspondence should be addressed to Wenli Cheng, wenlich@126.com Received 10 November 2011; Revised 12 March 2012; Accepted 3 April 2012 Academic Editor: S. H. Hong Copyright © 2012 Min Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The aim of the present paper was to investigate the effect of Shengjie Tongyu granule on vascular remodeling in atherosclerotic mice and the relevant underlying mechanism. Sixty male ApoE-gene-knockout mice, fed a high-fat diet from 6 weeks of age, were randomized into a Shengjie Tongyu granule group (4.00 g/kg/d), a simvastatin group (9.01 mg/kg/d), and a control group (normal saline: 0.2 mL/d). At the ages of 30 and 40 weeks, we sacrificed the mice for various measurements. The results show that treatment with Shengjie Tongyu granule and simvastatin significantly decreased lumen and plaque areas in the aortic root at 30 and 40 weeks of age, decreased grade II elastic fiber lesions in the ascending aorta at