spectroscopic studies of methimazole reactivity toward the aquapentacyanoferrate (ii) ion in aqueous solutions光谱的研究甲巯基咪唑反应向aquapentacyanoferrate(ii)离子在水解决方案.pdfVIP

Hindawi Publishing Corporation Spectroscopy: An International Journal Volume 27 (2012), Issue 5-6, Pages 509–514 doi:10.1155/2012/136058 Spectroscopic Studies of Methimazole Reactivity toward the Aquapentacyanoferrate (II) Ion in Aqueous Solutions ´ ´ ´ D. Cvijanovic, V. Damjanovic, I. Picek, and B. Foretic Department of Chemistry and Biochemistry, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia ´ Correspondence should be addressed to D. Cvijanovic, danijela.cvijanovic@mef.hr ´ Copyright © 2012 D. Cvijanovic et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract. Methimazole (2-mercapto-1-methylimidazole, MMI) and its pentacyanoferrate (II) complex have been charac- terized by means of UV/Vis, Raman, and NMR spectroscopy. The reaction of MMI with aquapentacyanoferrate (II), [Fe(CN) (H O)]3−, in buffered aqueous solutions yielded the [Fe(CN) (MMI)]3− complex. It was found that only thione 5 2 5 tautomer of MMI coordinates to the iron (II). The exceptionally stabile and inert complex was produced. Keywords: 2-mercapto-1-methylimidazole, pentacyanoferrate (II) complexes, spectroscopy 1. Introduction Methimazole (2-mercapto-1-methylimidazole, MMI) is known to have several chemotherapeutic applications, particularly in the treatment of thyroid disorders. The reactions and coordination ability of S, N -containing heterocyclic ligands such as MMI have been of considerable interest both from the structural point of view and pharmacological