sensitive spectrophotometric determination of atenolol in pharmaceutical formulations using bromate-bromide mixture as an eco-friendly brominating agent敏感光度法测定阿替洛尔在药品使用bromate-bromide混合物作为环保的溴化剂配方.pdfVIP

Hindawi Publishing Corporation Journal of Analytical Methods in Chemistry Volume 2012, Article ID 810156, 12 pages doi:10.1155/2012/810156 Research Article Sensitive Spectrophotometric Determination of Atenolol in Pharmaceutical Formulations Using Bromate-Bromide Mixture as an Eco-Friendly Brominating Agent Kudige N. Prashanth and Kanakapura Basavaiah Department of Chemistry, University of Mysore, Manasagangotri, Mysore 570006, Karnataka, India Correspondence should be addressed to Kanakapura Basavaiah, basavaiahk@yahoo.co.in Received 25 November 2011; Accepted 27 December 2011 Academic Editor: Dario Compagnone Copyright © 2012 K. N. Prashanth and K. Basavaiah. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Three simple and sensitive spectrophotometric methods are proposed for the determination of atenolol (ATN) in bulk drug and tablets. The methods are based on the bromination of ATN by the bromine generated in situ by the action of the acid on the bromate–bromide mixture followed by the determination of unreacted bromine by reacting with a fixed amount of either meta- cresol purple (MCP) and measuring the absorbance at 540 nm (method A) and 445 nm (method B) or erioglaucine (EGC) and measuring the absorbance at 630 nm (method C). Beer’s law is valid within the concentration ranges of 1.0–20.0, 2.0–40.0 and 1.0– 4 8.0 μg/mL for method A, method B and method C, respectively. The calculated molar absorptivities were found to be 1.20×10 , 3 4