the metabolism of baicalin in rat and the biological activities of the metabolites黄芩苷在大鼠的代谢和生物活性的代谢物.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 404529, 6 pages doi:10.1155/2012/404529 Research Article The Metabolism of Baicalin in Rat and the Biological Activities of the Metabolites Yi Wang,1, 2 Jingyu Yang,1 Xian Li,1 and Jinhui Wang1 1 Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Liaoing 110016, China 2 Key Laboratory of Marine Drugs, Chinese Ministry of Education and School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China Correspondence should be addressed to Yi Wang, wangyi0213@ and Jinhui Wang, wangjh1972@ Received 27 December 2011; Revised 15 February 2012; Accepted 6 March 2012 Academic Editor: Shuang-En Chuang Copyright © 2012 Yi Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Baicalin is one of the major bioactive constituents of Scutellariae Radix, but the biotransformation of it is poorly understood. In this paper, the metabolism of baicalin in rat was studied. Nine metabolites including one new compound were isolated and identified structurally. The plausible scheme for the biotransformation pathways of baicalin in the rats was deduced. And the main metabolites were evaluated for their antioxidation and anti-inflammation biological activities for the first time. 1. Introduction investigated. It is the first time that the metabolism and the bioactivities of the metabolites of baicalin were studied Scutellariae Radix, the root of Scutel