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the molecular biology of vestibular schwannomas and its association with hearing loss a review前庭神经鞘瘤的分子生物学及其与听力损失评估
Hindawi Publishing Corporation
Genetics Research International
Volume 2012, Article ID 856157, 10 pages
doi:10.1155/2012/856157
Review Article
The Molecular Biology of Vestibular Schwannomas and
Its Association with Hearing Loss: A Review
1 2 ´ 3 4
Erika Celis-Aguilar, Luis Lassaletta, Miguel Torres-Martın, F. Yuri Rodrigues,
Manuel Nistal,4 Javier S. Castresana,5 Javier Gavilan,2 and Juan A. Rey4
1 Instituto Nacional de Neurologıa y Neurocirugıa Manuel Velasco Suarez, 14269 Ciudad de Mexico, DF, Mexico
´ ´ ´
2 Department of Otolaryngology, “La Paz” University Hospital, 28046 Madrid, Spain
3 Unidad de Investigacion, Laboratorio Oncogenetica Molecular, “La Paz” University Hospital, 28046 Madrid, Spain
´
4 Department of Pathology, “La Paz” University Hospital, 28046 Madrid, Spain
5 Brain Tumor Biology Unit, CIFA, University of Navarra School of Sciences, 31009 Pamplona, Spain
Correspondence should be addressed to Luis Lassaletta, luikilassa@
Received 2 June 2011; Revised 8 October 2011; Accepted 3 November 2011
Academic Editor: Ignacio Del Castillo
Copyright © 2012 Erika Celis-Aguilar et al. This is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
cited.
Hearing loss is the most common symptom in patients with vestibular schwannoma (VS). In the past, compressive mechanisms
caused by the tumoral mass and its growth have been regarded as the
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