tnf-alpha in the locomotor system beyond joints high degree of involvement in myositis in a rabbit modeltnf在关节以外的运动系统高度的参与在兔肌炎模型.pdfVIP

Hindawi Publishing Corporation International Journal of Rheumatology Volume 2012, Article ID 637452, 11 pages doi:10.1155/2012/637452 Research Article TNF-Alpha in the Locomotor System beyond Joints: High Degree of Involvement in Myositis in a Rabbit Model 1 ¨ 1 2 1, 3 Sture Forsgren, Lina Renstrom, Craig Purdam, and James E. Gaida 1Anatomy Section, Department of Integrative Medical Biology, Umea University, 901 87 Umea, Sweden ˚ ˚ 2 Department of Physical Therapies, Australian Institute of Sport, Belconnen, ACT 2616, Australia 3 School of Primary Health Care, Monash University, Frankston, VIC 3199, Australia Correspondence should be addressed to Sture Forsgren, sture.forsgren@anatomy.umu.se Received 29 August 2011; Revised 3 November 2011; Accepted 4 December 2011 Academic Editor: Simone Appenzeller Copyright © 2012 Sture Forsgren et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The importance of TNF-alpha in arthritis is well documented. It may be that TNF-alpha is also markedly involved in muscle inflammation (myositis). An animal model where this can be investigated is needed. A newly developed rabbit myositis model involving pronounced muscle overuse and local injections of substances having proinflammatory effects was therefore used in the present study. The aim was to investigate the patterns of TNF-alpha expression in the developing myositis and to evaluate the usefulness of this