the neuroprotective effect of methanol extract of gagamjungjihwan and fructus euodiae on ischemia-induced neuronal and cognitive impairment in the rat甲醇提取的神经保护效应gagamjungjihwan和果实euodiae ischemia-induced神经和认知障碍的老鼠.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2011, Article ID 685254, 9 pages doi:10.1093/ecam/nep028 Original Article The Neuroprotective Effect of Methanol Extract of Gagamjungjihwan and Fructus Euodiae on Ischemia-Induced Neuronal and Cognitive Impairment in the Rat Bombi Lee,1 Eu-Jung Choi,2 Eun-Jung Lee,2 Seung-Moo Han,3 Dae-Hyun Hahm,1 Hye-Jung Lee,1 and Insop Shim4 1Acupuncture and Meridian Scientific Research Center, Kyung Hee University, Seoul, Republic of Korea 2 Department of Internal Medicine, Won Kwang University Chonju Oriental Hospital, Chonju, Republic of Korea 3 Department of Biomedical Engineering, Kyung Hee University, Suwon, Republic of Korea 4 Department of Basic Oriental Medical Science, Acupuncture and Meridian Science Research Center, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea Correspondence should be addressed to Insop Shim, ishim@khu.ac.kr Received 12 December 2007; Accepted 12 March 2009 Copyright © 2011 Bombi Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Gagamjungjihwan (GJ), a decoction consisting of five herbs including ginseng, Acori Graminei Rhizoma, Uncariae Ramulus et Uncus, Polygalae Radic and Frustus Euodiae (FE), has been widely used as herbal treatment for ischemia. In order to investigate the neuroprotective action of this novel prescription, we examined the influence of GJ and FE on learning and memory using the Morris water maze and studied their affects on the central cholinergi