Humanin及其衍生物结构生理功能与作用机制研究-中国细胞生物学.PDF

网络出版地址：/kcms/detail/31.2035.Q1045.006.html 中国细胞生物学学报 Chinese Journal of Cell Biology 2015, 37(3): DOI: 10.11844/cj cb.2015.03.0268 Humanin及其衍生物结构、生理功能与作用机制研究 闫 冰 钟历勇* (首都医科大学附属北京天坛医院内分泌科, 北京100050) ’ 摘要 Humanin(HN)是在阿尔茨海默病(Alzheimer s disease, AD)患者大脑枕叶皮层未受损 的脑区发现的一种由24个氨基酸组成的线性多肽, 能有效抑制多种家族性阿尔茨海默病(familial ’ β β β Alzheimer s disease, FAD)基因突变和 -淀粉样肽( -amyloid peptide, A )诱发的神经元凋亡, 起初被 认为是AD特异性的神经保护肽。然而近年来研究发现, humanin具有广谱的神经保护、细胞保护 与抗炎作用, 可改善胰岛素敏感性, 延缓糖尿病的发生。Humanin在多种疾病模型, 如AD 、2型糖 尿病、动脉粥样硬化、心肌缺血、脑卒中等发挥保护作用, 在以上疾病的防治中可能具有重要意义。 关键词 humanin; 衍生物结构; 生理功能; 神经保护; 细胞保护 Research Progress of Structure, Physiological Function and Action Mechanism of Humanin and Its Derivatives Yan Bing, Zhong Liyong* (Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China) Abstract Humanin (HN), a 24-amino-acid polypeptide, was first identified from the surviving neurons in occipital lobe of Alzheimer’s disease (AD) patients. Humanin inhibits neuronal cell death induced by various kinds of familial Alzheimer’s disease gene mutations and β-amyloid peptide, which was thought to be an AD specific neuroprotective peptide at first. However, many recent studies demonstrate that humanin possesses diverse neuro- protective, cytoprotective, and anti-inflammatory effects. Meanwhile, humanin can also improve insulin sensitivity, then delay o