DOPAMINE Middle East Technical University（多巴胺中东技术大学）.pdf

DOPAMINE RECEPTORS PREPARED BY: ORHAN ÖZCAN YASEMİN BAŞEĞMEZ ESRA GÜÇ OUTLINE • Functions of Dopamine • Dopamine Receptors structure • Dopamine Receptors – D1 D2 Family • Regulation of Dopamine Roles of Dopamine • Role in movement • Role in pleasure and motivation • Controls the flow of information from other areas of the brain Structure of Dopamine Receptors Dopamine Receptors • There are five types of dopamine receptors.D1,D2,D3,D4,D5. • We can catogorize dopamine receptors in two two main subtypes: • D1 like receptor family: the Gs protein is involved and adenylyl cyclase would be activated. The action of the enzyme causes the conversion of adenosine triphosphate to cyclic adenosine monophosphate (cAMP). • D2 like receptor family: which is the receptor combining with the Gi protein and its activated alpha- subunit then inhibits adenylyl cyclase so that the concentration of cAMP is reduced. Dopamine Receptors • Five subtypes of dopamine receptor have been cloned. The D1 and D5 receptors are closely related, and couple to Gs alpha and stimulate adenylyl cyclase activity. In contrast, the D2, D3 and D4 receptors couple to Gi alpha and inhibit the formation of cAMP. Distribution of Dopamine Receptors D1 receptors Most abundant receptor in the central nervous system Lack of intrones 446 aa Higly expressed in basal ganglia Chromosome 5 Stimulate AC D5 • Intronless • 477aa • 50% homology with D1 • Chrom