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片剂制备中四大辅料介绍(Introduction of four major excipients in the preparation of tablets)
片剂制备中四大辅料介绍(Introduction of four major excipients in the preparation of tablets)
In general, the tablet is composed of two kinds of material, one is to play a therapeutic drug (i.e. main medicine), the other is some substance has no physiological activity, the functions mainly include: filling effect, adhesion, disintegration and lubrication, sometimes also as a coloring agent and flavoring effect and cosmetic effect, in the pharmacy, usually these substances called excipients (Excipients or Adjuvants). They are often divided into four broad categories according to their different functions.
(I) diluent (Diluents)
The diluent (or as filler, Fil1ers) the main role is used to fill the tablet weight or volume, which is convenient for tabletting; commonly used fillers with starch, sugar, cellulose and inorganic salts; determined by tabletting process, preparation equipment and other factors, the tablet diameter not less than 6mm and weight in 100mg above, if the main tablet in a few milligrams or tens of milligrams, not adding filler, will not be made into tablets, therefore, thinner here plays a more important role to increase the volume, forming.
1. starch
Is common corn starch, its properties are very stable, and most of the drugs dont work, the price is relatively cheap, hygroscopic, good appearance, in the actual production, often with compressible powdered sugar, good dextrin mixed use, this is because the pressure of the poor starch, if used alone that will make the pressure of the tablet is too loose.
2. sugar
Sugar refers to white powder crystalline sucrose by low temperature after drying and crushing together, the utility model has the advantages of strong adhesion, can be used to increase the hardness of the tablet, and the tablet surface is smooth and beautiful, the disadvantage is that strong hygroscopicity, long-term storage, the tablet hardness is too large, disintegration and dissolution of difficulties. In addition to buccal tablets or soluble tablets,
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