皮肤对免疫系统的调控作用（The regulation of the skin on the immune system）.docVIP

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皮肤对免疫系统的调控作用（The regulation of the skin on the immune system）.doc

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皮肤对免疫系统的调控作用（The regulation of the skin on the immune system）

皮肤对免疫系统的调控作用（The regulation of the skin on the immune system） The regulation of the skin on the immune system Figure 1: normal skin and inflammatory skin conditions, keratinocytes, Langerhans cells and T cells Interaction - A phenomenon that has puzzled scientists for a long time, UV light suppresses the immune response of the skin and finally gets it Scientific explanation. Light and a number of other stimuli promote the skin cell RANKL (receptor activator) The expression of of, NF-K, B, ligand) promotes regulatory T cells (regulatory, T, cells, Tregs) Multiplication. The skin is always exposed to environmental stimuli, which is likely to cause imbalances in the immune system. For example, when the skin is exposed to UV light, the immune system is inhibited: UV light can be partially treated Autoimmune diseases of psoriasis (psoriasis). Now, Loser has found a clue for us to explain some environmental stimuli, such as UV Certain skin inflammation caused by light inhibits local and systemic immune responses [1]. They outlined one A range of cellular and molecular kinetic maps revealed that epidermal inflammation activates the skin keratinocytes (keratinocyte) Selective proliferation of regulatory T cells (Tregs) (preferential, expansion); regulatory T cells are a class of cells that inhibit physiological and pathological immune responses in the skin and other tissues. Tregs, to be precise, naturally occurring is CD25+CD4+ Tregs (see Note 1) that can be specific The transcription factor Foxp3 is expressed, which maintains the tolerance (self) of the immune system and inhibits it Disorders or excessive immune responses, such as autoimmune diseases and allergies (Allergy), etc. (2). Interleukin - 2 (Interleukin-2; IL-2) is the natural Tregs (NATURAL Tregs) in the peripheral immune system (peripheral, immune, system) an indispensable cytokine in survival; CD25 (IL-2 receptor) The a strand is also integral to its involvement in the formation of high affinity IL-2 receptor