硫辛酸治疗糖尿病足的临床观察（Clinical observation of lipoic acid in treatment of diabetic foot）.doc

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硫辛酸治疗糖尿病足的临床观察（Clinical observation of lipoic acid in treatment of diabetic foot）.doc

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硫辛酸治疗糖尿病足的临床观察（Clinical observation of lipoic acid in treatment of diabetic foot）

硫辛酸治疗糖尿病足的临床观察（Clinical observation of lipoic acid in treatment of diabetic foot） Clinical observation of Thioctic Acid Injection in the treatment of diabetic foot Zhang Jigang Zang Yixian Advisory: 029-3205-6936 186-9106-9128 Abstract: Objective: To investigate the clinical efficacy and safety of lipoic acid in diabetic foot (DF). Methods: according to the diagnostic criteria of WHODF, 98 cases of diabetic foot patients were randomly divided into two groups: treatment group 50 cases, fasting blood glucose (11.6 + 3) mmol/L; control group 48 cases, fasting blood glucose (11.2 + 2.8) mmol/L. The control group was treated with basic treatment (including diet control, insulin to control blood sugar, effective antibiotics to control infection, decompression, surgical treatment); treatment group on the basis of the above plus lipoic acid 600mg intravenous injection, 1 times a day, a total of 28 days. Results: the clinical efficacy in the treatment group had a significant difference compared with the control group, the treatment group before treatment, m/ blood flow velocity in the dorsal hemodynamics (s.mm) was 0.34 + 0.13 after treatment, blood flow velocity, m/ (s.mm) 0.84 + 0.16, the control group before treatment, the blood flow velocity of m/ (s.mm) 0.35 0.18, after treatment, the blood flow velocity of m/ (s.mm) 0.61 + 0.11 (p0.01), in terms of nerve conduction of common peroneal nerve (Mcv + s, m/s) before the treatment, 38.13 + 4.51, 43.67 + 4.20 after treatment; the control group before treatment was 38.70 + 4.42, 43.67 + 4.20 after treatment (p0.05) the superficial peroneal nerve, Scv (s, m/s) before the treatment, 36.76 + 1.89, 42.12 + 3.16 after treatment; the control group before treatment was 37.13 + 1.86 After treatment, 39.32 + 2.78 (p0.05) conduction velocity was significantly improved. Conclusion: This study shows that Thioctic Acid Injection has remarkable curative effect in the treatment of diabetic foot, and can improve the hemodynamics of the dorsum