细胞外基质构成的生物支架（Biological scaffold composed of extracellular matrix）.docVIP

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细胞外基质构成的生物支架（Biological scaffold composed of extracellular matrix）.doc

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细胞外基质构成的生物支架（Biological scaffold composed of extracellular matrix）

细胞外基质构成的生物支架（Biological scaffold composed of extracellular matrix） A scaffold composed of CNS extracellular matrix Institute of regenerative medicine, University of Pittsburgh, published in Biomaterials abstract Acellular biological scaffold (acellular biological scaffold) Widely used in connective tissue, epithelial tissue, muscle tissue, these three traditional types of tissue remodeling. However, the use of acellular matrix (ECM) scaffolds in nerve tissue is limited, especially in the central nervous system (CNS), where the intrinsic regenerative potential is low. The ability to remove cells, liver, lung, muscle, and other tissues supporting the phenotype and function of certain tissue cells suggests that CNS derived biological scaffolds may be barriers to customer satisfaction for mammalian CNS repair. We have designed a method of acellular by validated standards, designed a way to create CNS ECM scaffolds from the pigs optic nerve, spinal cord, and brain. CNS ECM scaffolds retain nerve support proteins and growth factors, which are cellular compatible and stimulate proliferation, transplantation, and differentiation when tested in vitro with PC12 cells. Bladder ECM (non CNS ECM scaffold) is also cellular and can stimulate proliferation of PC12 cells, but the graft is blocked, Compared with CNS ECM, it could not induce the same concentration range of chemical inducers when inducing greater PC12 cell differentiation rate. These results suggest that CNS ECM CNS may provide specific advantages in regeneration of tissues in medical applications, and ECM stent can usually in CNS damage after recovery of function. 1, introduction ECM is the secretory product of resident cells of every tissue and organ, and therefore logically defines the ideal matrix or scaffold that can be used to obtain tissue-specific cell phenotypes. ECM is a critical determinant of cellular behavior and is believed to influence intracellular signaling, cell differentiation, and cell proliferation