美洛昔康片（Meloxicam Tablets）.docVIP

美洛昔康片（Meloxicam Tablets） Meloxicam Tablets (Meloxicam Tablets) This product is the main ingredients of meloxicam, chemical name: 4- hydroxy -2 methyl -N- (5- methyl -2- thiazolyl) -2H-1, 2- -3- phenothiazine formamide -1 dioxide, 1. [traits] This product is light yellow. [pharmacology and toxicology] Pharmacological action: This product is non steroidal anti-inflammatory drugs. It has analgesic, anti-inflammatory and antipyretic effects on animal models. The mechanism may be related to the inhibition of prostaglandin synthesis. Carcinogenicity: Rats of the 0.8mg/kg/ day (1.4 times according to the surface area at the equivalent of the clinical recommended dose) with continuous oral administration for 104 weeks and the mice 8mg/kg/ (2.2 times according to the surface area at the equivalent of the clinical recommended dose) continuous oral administration for 99 weeks showed the goods are carcinogenic effect. Genotoxicity: the product Amcs test, human lymphocyte chromosome aberration test and mouse bone marrow micronucleus test were negative. Reproductive toxicity: male rats and female rats by oral dosage of this product is up to 9mg/kg/ and 5mg/kg/, respectively (according to the surface area of conversion were equivalent to adult clinical recommended dose of 4.9 times and 2.5 times), had no obvious effect on the fertility of male and female rats. But in the early development of female rats for 2 weeks prior to mating and embryos treated with this dosage more than 1mg/kg/ day (0.5 times according to the surface area at the equivalent of adult clinical recommended dose) when the stillbirth rate increased. The rabbits in the formation of the whole organ after oral administration of 60mg/kg/ on the product (64.5 times according to the surface area at the equivalent of the clinical recommended dose) can cause cardiac septal defect (this is a very rare phenomenon) increase in the incidence of more than 5mg/kg/ days, dose (5.4 times according to the surface area at the equi