肾病综合征并发症大全（Complete list of complications of nephrotic syndrome）.docVIP

肾病综合征并发症大全（Complete list of complications of nephrotic syndrome） Complete list of complications of nephrotic syndrome (a) The main reason for the decline in resistance to infection in patients with nephrotic syndrome is due to the loss of large amounts of IgG in the urine. The deficiency of B factor (the component of complement alternative pathway) leads to the defect of the immune nursing efficacy of bacteria. When malnutrition occurs, the nonspecific immune response of the organism is weakened and the immune function of the organism is damaged. Large amounts of transferrin (PRO) and zinc were lost from urine. Transferrin (PRO) is essential for the maintenance of normal lymphocyte function, and the concentration of zinc ion is related to thymosin synthesis. Local factor. Pleural effusion, ascites, high skin edema caused by skin rupture and severe edema, local body fluid factor dilution, defensive function weakened, are all susceptible factors of nephrotic syndrome patients. Prior to the advent of antibiotics, bacterial infections were one of the leading causes of death in patients with nephrotic syndrome. Severe infections occurred mainly in children and the elderly, and adults were rare. The common clinical infection: primary peritonitis, cellulitis, respiratory tract infection and urinary tract infection. Once the infection is confirmed, it should be treated immediately. (two) Hypercoagulable state and venous thrombosis nephrotic syndrome have hypercoagulable state, mainly because of coagulation factor change in blood. Including IX, Xi and VIII factor decreased, V, factor X, fibrinogen (PRO), beta thromboglobulin (PRO) and platelet levels increased. Adhesion and aggregation of platelets are enhanced. Antithrombin III and plasmin activity decreased. Therefore, the increase of procoagulant and procoagulant factors, the decrease of anti coagulation and anti coagulation factors and the damage of fibrin (PRO) dissolution mechanism are the causes of hypercoagulability