脂肪肝的病因（The etiology of fatty liver）.docVIP

脂肪肝的病因（The etiology of fatty liver） The related factors that promote the formation of fatty liver are: (1) excessive fatty acid entering the liver and excessive intake of fat lead to hyperlipidemia. The intake of carbohydrate metabolic disorders, or too little use bad, cortical hormone secretion increased and increased sympathetic nervous activity, fatty acid mobilization from fat in the library increased, poured into the liver, than it can handle, prompting the formation of fatty liver. (2) the formation of hepatic triglyceride increase or reduce excessive intake of carbohydrate oxidation, alpha glycerophosphate and acetyl coenzyme A increased in metabolic process, providing raw materials for the synthesis of a large number of triglycerides; hepatic fatty acid oxidation reduction or esterification enhancement; directly or indirectly increase the intrahepatic triglyceride. (3) lipoprotein synthesis reduces or releases obstruction. Triglycerides are mainly bound to apolipoproteins and transported to the bloodstream in the form of lipoproteins. Hepatocyte synthesis requires apolipoprotein ATP and polysomes. Because of the rough endoplasmic reticulum injury of liver cells, ATP decreased, apolipoprotein synthesis decreased; lipoprotein phospholipid is synthesis of raw materials, lack of essential fatty acid and choline, the synthesis of phospholipids in liver decreased, affecting the synthesis of lipoproteins; hepatocyte dysfunction, caused by triglyceride and apolipoprotein binding obstruction; lipoprotein the decreased synthesis of triglycerides can not effectively output, while in the liver. The incidence of fatty liver is higher, which is closely related to the improvement of peoples living standard and the change of dietary structure. It includes nutritional disorders, heavy drinking, diabetes, hepatitis, metabolic and endocrine disorders and many other reasons. A: long term alcohol: alcohol is the first killer of liver damage, this is because the alcohol into the