Strategies for drug delivery through the blood-brain barrier通过血脑屏障的药物递送策略.pptVIP

Introduction to CNS pharmacology Anne McKinney Microanatomy Neurons Non-neuronal -Microglia -Microglial related macrophages -Cells of the cerebral vasculation -Meninges c) Blood brain barrier Blood brain barrier (BBB) Cortical microvasculature The BBB has several functions Protects the brain from “foreign substances” in the blood that my injure the brain Protects the brain from hormones and neurotransmitters in the rest of the body Maintains a constant environment for the brain General properties Large molecules do not pass through the BBB easily Low lipid (fat) soluble molecules do no