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The renaissance of immunotherapy is a （免疫疗法是一个文艺复兴时期）
The renaissance of immunotherapy is a revolution
for cancer patients and for oncology
Ira Mellman, Ph.D.
Vice President, Cancer Immunology, Genentech
1
The renaissance of immunotherapy is a revolution
for cancer patients
Traditional drug development
Is linear development path the best approach?
Generate Test Verify
Launch
Hypothesis Hypothesis Hypothesis
Early Late
Research Marketing
Development Development
Cancer immunotherapy requires a cyclical
“learning organization”
Post-Launch Research
Cancer Immunotherapy
Strategy Group
(CITS)
Late Development Early Development
FIR PII 1/2L Dx+ ORR
BIRCH
PII Dx+ ORR
POPLAR PII 2L+ Dx+/- vs. Doce OS
OAK PIII 2L+ Dx+/- vs. Doce OS
Cancer immunotherapy at Genentech/Roche
Pipeline overview
Pre-clinical Phase I Phase II Phase III
Anti-PDL1 Anti-PDL1 Anti-PDL1
ImmTAC
Solid tumors NSCLC (Dx+) NSCLC 2/3 L
Ant
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