+6 Gz and noise multiple stress on learning and memory function(+ 6广州和噪声多重压力对学习和记忆功能).docVIP

+6 Gz and noise multiple stress on learning and memory function(+ 6广州和噪声多重压力对学习和记忆功能).doc

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6Gzandnoisemultiplestressonlearningandmemoryfunction(6广州和噪声多重压力对学习和记忆功能)

+6 Gz and noise multiple stress on learning and memory function Author: Xi-Qing Sun, Ting Liu Song, FORCES, Xing-Yu Wu [Keywords] noise [Abstract] AIM: To study the effects of combined stress of noise and moderate + Gz on learning and memory in rats. METHODS: Thirtytwo male SD rats were randomly divided into four groups with 8 rats in each group: control group, +6 Gz / 3 min group, 90 dB (A) / 30 min noise group, +6 Gz / 3 min and 90 dB (A) / 30 min noise combined stress group and the changes of learning and memory after stress were measured by Ymaze test and stepthrough test. RESULTS: As compared with that in control group, the percentage of right reaction decreased significantly (P0.01) and the reaction time increased significantly (P0.01) in + Gz group at 2 d, 4 d and 6 d after + Gz exposure. When compared with that in control and noise group, the percentage of right reaction decreased significantly (P0.01) and the reaction time increased significantly (P0.01) at all time points in combined stress group, but no significant changes were observed when compared with that in + Gz group. As compared with that in control group, the total time and number of error increased significantly (P0.01) while latent time decreased significantly immediately and 6 days after stress (P0.05) in combined stress group. CONCLUSION: It is suggested that combined stress of +6 Gz/30 min and 90 dB (A) / 30 min noise may cause sustained impairment of learning and memory in rats. [Keywords] stress; + Gz; noise; learning and memory; rats [Abstract] Objective: To investigate the moderate-intensity positive acceleration and noise impact of multiple stress on learning and memory function in rats Methods: Male SD rats were randomly divided into control group, +6 Gz / 3 min group, 90 dB (A ) / 30 min noise group, +6 Gz / 3 min and 90 dB (A) / 30 min noise composite stress group four groups, each of eight Y-maze test and passive avoidance test observed stress at different times cha

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