制备3,3,3-三氟丙酸.pdfVIP

Journal of Fluorine Chemistry, 21 (1982) 99-106 99 Received:February 11, 1982 SYNTHESIS OF 3,3,3-TRIFLUOROPROPIONIC AND 4,4,4-TRIFLUORO-E-KETOBUTYRICACIDS C. WAKSELMAN and M. TORDEUX C.N.R.S.-C.E.R.C.O.A. 2, rue Henri Dunant 94320 THIAIS (France) SUMMARY Trifluoroethyl cyclohexyl ketone (4) is prepared by acylation of difluoroethylene (2) with cyclohexanecarboxylic acid chloride (A), followed - by Cl*F exchange with potassium fluoride in