about the ventral tegmental area microinjection of mk（可对腹侧被盖区显微镜下注射）.docVIP

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2017-09-05 发布于浙江
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about the ventral tegmental area microinjection of mk（可对腹侧被盖区显微镜下注射）.doc

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about the ventral tegmental area microinjection of mk（可对腹侧被盖区显微镜下注射）

About the ventral tegmental area microinjection of MK Papers network: [Keywords] morphine dependence [Abstract] AIM: To study whether the blockade of glutamate NMDA receptors in the ventral tegmental area (VTA) modulates the morphine withdrawal in rats. METHODS: The effects of (+) MK801, microinjected unilaterally into the VTA 30 min before naloxone (2 mg / kg, ip) administration, on the morphine withdrawal were assessed. Morphine dependence developed with increasing morphine injection (ip) and morphine withdrawal was induced by injection (ip) of naloxone (2 mg / kg). Wet dog shakes and GellertHoltzman score were used as the indexes to evaluate the intensity of morphine withdrawal. RESULTS: Unilateral microinjection of MK801 into the VTA significantly reduced the GellertHoltzman score and the incidence of wet dog shakes in morphine withdrawal rats. CONCLUSION: MK801 (2, 5, 10 g / L) unilaterally administered into the VTA significantly reduces the intensity of morphine withdrawal syndrome in dependent rats. These data support that glutamatergic transmission in the VTA and its interactions with dopaminergic neurons in the mesolimbic system play some important roles in opiate withdrawal syndrome. Our findings also suggest a potential use of NMDA antagonists in the therapeutic treatment of opiate abuse. [Keywords] MK801; Morphine deperdence; substance withdrawal syndrome; receptors, NmethylDaspartate; Rats; ventral tegmental area [Abstract] Objective: To study the brain - the edge of dopamine circuit ventral tegmental area (VTA) of endogenous glutamate signal transduction role in the formation of the morphine withdrawal. Methods: VTA micro-injection of different doses of glutamate NMDA receptor antagonist (+ MK801, to observe the impact of the withdrawal symptoms of morphine withdrawal rats with behavioral methods. increments of morphine to establish dependency model ip 7 d, the last administration, 1.5 h ip naloxone hydrochloride (2 mg / kg induced withdrawa