HIVAIDS病人合并血流感染的病原菌分布特点.docVIP

HIV/AIDS病人合并血流感染的病原菌分布特点 丁秀荣 ，于艳华，陈铭，李虹曼，娄金丽 （首都医科大学 附属北京佑安医院 临床检验中心，北京100069） 摘要：目的 探讨艾滋病病毒（HIV）感染者/艾滋病（AIDS）病人（简称HIV/AIDS病人）合并血流感染病原菌的分布特点，为临床诊疗提供参考。方法 回顾性分析76例血培养阳性的HIV/AIDS病人的临床资料，并与同期普通病人的资料进行比较。结果 研究期间，共收集血培养阳性菌株1263株，其中79株分离自HIV/AIDS病人的血培养标本，1184株菌分离自普通病人的血培养标本。HIV/AIDS病人血培养病原菌主要以分枝杆菌最常见(22.8%)，其次是马尔尼菲青霉菌（21.5%）和新型隐球菌（11.4%）；普通病人血培养病原菌则以大肠埃希菌（23.1%）、肺炎克雷伯菌（13.3%）和屎肠球菌（6.6%）最常见。两组病人真菌感染的比例有显著差异（P0.001），且真菌的菌种分布明显不同。结论　HIV/AIDS病人易发生由分枝杆菌和马尼菲青霉菌等引起的血流感染，临床上应加强对HIV/AIDS病人血流感染病原菌的监测，积极防治血流感染的发生。 关键词：艾滋病；血培养；病原菌分布特点中图分类号： R.9; R512.91 文献标志码： A 文章编号：1672-5662（201）-0000-00 Analysis of pathogen spectrum of bloodstream infection in HIV/AIDS patients Ding Xiurong, Yu Yanhua, Chen Ming, Li Hongman, Lou Jinli.(Clinical Laboratory Centre, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China） Corresponding author: Lou Jinli, Email: loujinlilab@163.com Abstract: Objective To explore the distribution characteristics of pathogens in patients with HIV/AIDS and blood stream coinfection, and to provide reference to improve diagnosis and treatment. Methods The clinical data of 76 HIV/AIDS patients with bloodstream infection were analyzed retrospectively, and compared with the patients purely infected with bloodstream as controls. Results A total of 1 263 strains of pathogens were isolated from the blood specimens, of which 79 strains were isolated from patients infected with HIV/AIDS, and 1 184 strains from patients without HIV/AIDS infection. The most common pathogenic bacteria of HIV/AIDS patients were mycobacterium,?accounting for 22.8%, followed by penicilliosis marneffei (21.5%) and cryptococcus neoformans (11.4%). Among the patients not infected with HIV, the first three pathogenic bacteria were escherichia coli (23.1%), klebsiella pneumoniae (13.3%), and enterococcus faecium (6.6%). There were higher incidences of bloodstream fungal (infection) in patients with HIV/AIDS than those in control group (P0.01). The distribution o