止哮平喘方对哮喘大鼠嗜酸性粒细胞凋亡与调控基因表达影响.pdf

3．8大鼠肺组织EOS凋亡及Fas，Bcl-2mRNA的表达 4结论 以OVA致敏和激发，可以成功复制大鼠哮喘模型．止哮平喘方能通过 直接松弛气管平滑肌，解除气道痉挛；降低全血和BALF中自细胞及EOS 数量；降低血清IgE、IL-5、IL-1 3含量；促进肺组织FasmRNA表达、抑 炎症，抑制气道高反应性和气道重塑，发挥平喘作用。 主题词哮喘；气道炎症；细胞凋亡；基因表达； @止哮平喘方 m ofZhi XaoPi onEosi i I i Sand Effect i ngChuanFangnophApoptos i n i onofCentreI I i GeneAsthmati cRats Express ng i aI i i ti onaI Chi neseI nternaI Medi ci Re Specty=Trad Author=Pan Fengman Tutor=Professor WangPeng Abstract 1 ire： Object To invest theeffectSof on igate asthmatic overflow of symptomscores，pulmonary trachealin countof and in vitro，the strips leukocyteeosinophil content wholebloodandbronchialalveolarfluid(BALF)，the lavage ofI and in iS of IL一13 serum，H gE，IL一5 tomorphology t remodel of and Fas，Bcl一2mRNA iSSUe，airwaying，expression cos 1 iS in tiSSUC．Theeffectivemechanismof inophiapoptoslung onimmune inflammation， response，airway ZhiXia0PingChuanFang ai iveness andai remodelofasthmawere rwayhyperrespons rway ing explored． 2Methods： rat modelwasestablishedsensitizationand