IL-5-ET及CGRP在变应性鼻炎中表达.docVIP

IL-5\ET及CGRP在变应性鼻炎中表达[摘要] 目的：测定变应性鼻炎（allergic rhinitis，AR）患者血中白细胞介素-5（IL-5）、内皮素（ET）及降钙素基因相关肽（CGRP）水平的变化，观察它们在变应性鼻炎中的作用及相互关系，为变应性鼻炎的发病机制、发展及治疗提供依据。方法：选择变应性鼻炎患者36例，慢性鼻-鼻窦炎(chronicrhinosinusitis，CRS)32例，健康对照组30例。分别测定血清IL-5、血浆ET及CGRP水平。结果：IL-5、ET及CGRP含量在变应性鼻炎患者血中较慢性鼻-鼻窦炎患者有明显增高，IL-5、ET及CGRP含量分别为（88.25±33.47）、（77.81±8.26）、（45.32±7.35） ng/L，显著高于慢性鼻-鼻窦炎组[(44.34±16.32)、（72.53±8.34）、（40.07±7.13） ng/L]及健康对照组[（31.24±8.43）、（66.12±7.73）、（35.53±8.02） ng/L]。慢性鼻-鼻窦炎与健康对照组比较亦有明显差异。结论：IL-5、ET及CGRP在变应性鼻炎患者血液中含量较高，它们可能参与了变应性鼻炎的病理生理过程，其变化可能与变应性鼻炎的发生、发展有关。 [关键词] 变应性鼻炎；白细胞介素-5；内皮素；降钙素基因相关肽 [中图分类号] R765.21 [文献标识码]A [文章编号]1674-4721（2010）11（a）-009－０2 Expression of interleukin-5， endothelin and calcitionin gene-related peptide in allergic rhinitis WANG Xiaojie1, HAO Yue1, ZHAO Daqing2* (1.Depautment of Otorhinalaryngology, Changping People′sHospital, Guangdong Province,Dongguan523573,China;2.Department of Otorhinalaryngology,Xijing Hospital of Fourth Military Medical University,Shaanxi Province, Xi′an 710033,China) [Abstract] Objective:To detect expression of interleukin-5, endothelin and calcitonin gene-related peptide in the blood of allergic rhinitis(AR) patients,and observe the relationship between them. Methods: 36 cases with AR,32 cases with CRS and 30 healthy individual served as control group. The levels of interleukin-5 and ET and CGRP were measured and analyzed. Results:IL-5 and ET and CGRP levels[（88.25±33.47）、（77.81±8.26）、（45.32±7.35） ng/L]were significantly higher in AR than in CRS[(44.34±16.32)、（72.53±8.34）、（40.07±7.13） ng/L]. IL-5 and ET and CGRP levels were significantly higher in CRS than control. Conclusion: It is found that concentrations of IL-5，ET and CGRP rised significantly in AR. IL-5, ET and CGRP may be involved in pathogenesis of AR and be related with the development of AR. [Key words] Allergic rhinitis; Interleukin-5; Endothelin; Calcitonin gene-related peptide 变应性鼻炎(allergic rhinitis, AR)在全球发病率呈逐年上升趋势，近年对其病因、发病机制、诊断以及治疗各个环节的研究都得到空前重视。目前已知有多