菌丝形态分化与头孢菌素C合成的关系.pdf

2005 32 ( 1) 15 C* 1 1 1* * 1 1 万 平 冀志霞 储 炬 庄英萍 张嗣良 ( 200237) 1 ( 318000) 2 : , , , , : , , , , : TQ9206 : A : ( 2005) A Relationship Betw een Cepalosporin C Synthesis andM orphologicalD ifferentiation by Cep ha losp or ium acrem on ium 1 1 1* 1 1 WAN Ping JI ZhiX ia HU Ju ZHUANG Y ingP ing ZHANG SiL iang ( S ta te K ey L aboratory of B ioreac tor E ng in eering, ECUST, Shang hai 200237) 1 (Zh ej iang H isun Pha rma ceu tica C oL td , T aizhou 318000) 2 Abstract: Themorphologies ofC ep ha osp orium acrem on ium were quantitatively analysed by biomi age analysisThevari ations of the cellmorphologies during cepalosporin fermentation were studied statistically In particular, the parame ters representing themycelia growh, such as totalhyphal length, hyphalw idth, mean hyphal grow th unit, werequantita tively analysed, and the relationship between cepalosporin synthesis andmorphological differentiation was investigated systmi aticallyThe cepalosporin synthesiswas initiated whenmorphological differentiation from filamentoushyphae in to highly swollen hyphal fragments was happened Further more, cepalosporin was mainly produced during the process of making highly swollen hyphal fragments into conidias K ey words: C ep ha osp orium a cremonium, Image analysis, M orphological differentiation, M ean hyphal grow th unit, epalosporin , [ 1] NashHuber , 4 : , (), ; [ 2] Matsumura ,