酪氨酸衍生物的合成及其凝胶性能的分析研究.pdfVIP

明CPFX 对 BDT 水凝胶的 TGS 和粘弹性有相似的影响。随着 CPFX 加入量增大 TGS 和粘 弹性增大，在 CPFX/BDT = 0.3 时最大，继续加入 CPFX 则会减小，这与 CPFX 在凝胶 中的存在方式有关。通过 SEM 分析不同载药量的 BDT 凝胶的微观结构，结合 CPFX 和 BDT 的结构特点，推断出 CPFX 在凝胶中可能有 3 种不同的存在方式。 （6 ）研究了 CPFX 在 BDT 水凝胶静态下的扩散释放规律，结果表明，胶凝剂浓度 固定时随着载药凝胶中 CPFX 浓度的增大，CPFX 的累积释放量增大；CPFX 含量相同 的 BDT 凝胶其胶凝剂的浓度越大累积释放率越低。不同胶凝剂浓度、相同 CPFX/BDT 比值的凝胶累积缓释率基本相同。BDT 凝胶对 CPFX 具有良好的缓释效果，其缓释行为 受凝胶的稳定性和微观形貌影响。 关键词：小分子凝胶； 胶凝剂； 氨基酸衍生物； 缓释 研究类型：应用基础 Subject : Synthesis and Gelation Properties of Tyrosine Derivatives Specialty : Applied Chemistry Name : Ma Xiaodan （signature） Instructor : Zhou Anning LiYuangang （signature） ABSTRACT Low-molecular-mass organic gels (LMOG) have numerous potential practical applications in preparation of nano materials, environmental management, drug delivery, etc, which is due to their completely thermal reversibility, special self-assembly, stimuli-responsible and other properties. It is an important research direction in this field how to design and synthesize simple gelator molecules, easy to synthesize and available in large quantities from cheap starting materials, and study the relation between their structure and gel performance. In this thesis, new tyrosine-based gelators were designed and synthesized. The relation between gelation properties and the structure of these tyrosine-based molecules, as well as the morphology and molecular packing fashion of LMOG were studied. On this basis, the BDT hydrogel have been investigated in the field of drug delivery. 1 (1) The results from TLC, H-NMR and FTIR analysis confirmed that new Tyrosine derivatives, nam