a highly efficient bismuth salts-catalyzed route for the synthesis of α-aminophosphonates一种高效铋salts-catalyzedα-aminophosphonates的合成路线.pdfVIP

Molecules 2010, 15, 8205-8213; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article A Highly Efficient Bismuth Salts-Catalyzed Route for the Synthesis of α-Aminophosphonates Antara Banik †, Sahil Batta †, Debasish Bandyopadhyay and Bimal K. Banik * Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, TX 78541, USA † High school research participants. * Author to whom correspondence should be addressed: E-Mail: banik@; Tel.: +1-956-665-8741; Fax: +1-956-665-5006. Received: 24 September 2010; in revised form: 5 October 2010 / Accepted: 9 November 2010 / Published: 12 November 2010 Abstract: A convenient synthesis of different types of α-amino phosphonates via one-pot solvent-free three component reactions of aldehydes, amines and phosphites catalyzed by bismuth salts has been investigated. Bismuth triflate is found to be the most effective catalyst for this reaction. Keywords: bismuth salts; catalysis; imines; phosphites; α-aminophosphonates 1. Introduction The synthesis of α-aminophosphonates has received the attention of organic chemists as they represent structural analogues of the important α-amino acids. Various uses of α-amino phosphonates as antimicrobial [1-3], antioxidant [2], antitumor [4-6], antiviral [7] and enzyme inhibitors [8-10] have been discovered. A number of synthetic methods for the construction of α-aminophosphonates have been reported [11] but the nucleophilic