a new approach for detecting low-level mutations in next-generation sequence data检测到低水平的突变的新方法新一代的序列数据.pdfVIP

Li and Stoneking Genome Biology 2012, 13:R34 /2012/13/5/R34 METHOD Open Access A new approach for detecting low-level mutations in next-generation sequence data * Mingkun Li and Mark Stoneking Abstract We propose a new method that incorporates population re-sequencing data, distribution of reads, and strand bias in detecting low-level mutations. The method can accurately identify low-level mutations down to a level of 2.3%, with an average covera