a novel antibacterial compound from siegesbeckia glabrescens一种新型抗菌化合物从siegesbeckia glabrescens.pdfVIP

Molecules 2012, 17, 12469-12477; doi:10.3390/molecules171112469 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article A Novel Antibacterial Compound from Siegesbeckia glabrescens Young-Soo Kim 1,†, Hyungil Kim 1,†, Eunsun Jung 1, Jang-Hyun Kim 2, Wangtaek Hwang 1, Eun-Ju Kang 1, Sanghyun Lee 3, Byung-Jo Ha 4, Jongsung Lee 4 and Deokhoon Park 1,* 1 Biospectrum Life Science Institute, Eines Platz 11th FL, #442-13 Sangdaewon Dong, Seongnam City, Gyunggi Do 462-120, Korea 2 Dermiskin, 44-9 Chongho Ri, Jinwi Myeon, Pyeongtaek City, Gyunggi Do 451-862, Korea 3 Department of Integrative Plant Science, Chung-Ang University, Anseong City, Gyunggi Do 456-756, Korea 4 Department of Dermatological Health Management, EulJi University, Seongnam City, Gyunggi Do 461-713, Korea † These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: pdh@; Tel.: +82-31-750-9400; Fax: +82-31-750-9494. Received: 15 August 2012; in revised form: 18 October 2012 / Accepted: 19 October 2012 / Published: 24 October 2012 Abstract: The crude methanol extract of the dried aerial parts of Siegesbeckia glabrescens (Compositae) showed antibacterial activity against the foodborne pathogen Staphylococcus aureus. Bioactivity-guided separation led to the isolation of 3-(dodecanoyloxy)-2- (isobutyryloxy)-4-methylpentanoic acid from nature for the first time. The structure was determined by spectroscopic data analysis (UV, MS, and NMR). The minimal inhibitory