a novel anti-inflammatory role for ginkgolide b in asthma via inhibition of the erkmapk signaling pathway一种新型抗炎作用ginkgolide b通过抑制哮喘erkmapk信号通路.pdfVIP

Molecules 2011, 16, 7634-7648; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article A Novel Anti-Inflammatory Role for Ginkgolide B in Asthma via Inhibition of the ERK/MAPK Signaling Pathway Xiao Chu 1,†, Xinxin Ci 1,†, Jiakang He 2,†, Miaomiao Wei 1, Xiaofeng Yang 1, Qingjun Cao 3, Hongyu Li 1, Shuang Guan 1, Yanhong Deng 1, Daxin Pang 4,* and Xuming Deng 1,* 1 Key Laboratory of Zoonosis Ministry of Education, Institute of Zoonosis, College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, China 2 College of Animal Science and Technology, Guangxi University, 100 Daxue Road, Nanning 530005, Guangxi, China 3 College of Plant Science, Jilin University, Changchun 130062, China 4 Key Laboratory of Animal Embryo Engineering, Department of Animal Biotechnology, College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, China † These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mails: pdx@ (D.X.P.); xumingdeng@ (X.M.D.); Tel.: +86-431 Fax: +86-431 Received: 19 July 2011; in revised form: 11 August 2011 / Accepted: 16 August 2011 / Published: 6 September 2011 Abstract: Ginkgolide B is an anti-inflammatory extract of Ginkgo biloba and has been used therapeutically. It is a known inhibitor of platelet activating factor (PAF), which is important in the pathogenesis of asthma. Here, a non-infectious mouse model of asthma is used to evaluate the