a theoretical model for estimating the margination constant of leukocytes一个理论模型估计着边常数的白细胞.pdfVIP

BMC Physiology BioMed Central BMC Physiology 2 2002, Research article A theoretical model for estimating the margination constant of leukocytes 1 2 Kátia Iadocicco , Luiz Henrique Alves Monteiro and José Guilherme Chaui- Berlinck*1 Address: 1Departamento de Fisiologia, Instituto de Biociências, Universidade de São Paulo 05508-900 São Paulo, SP, Brazil and 2Pós-Graduação, Engenharia Elétrica, Universidade Presbiteriana Mackenzie, São Paulo, SP, Brazil E-mail: Kátia Iadocicco - kiadocic@usp.br; Luiz Henrique Alves Monteiro - luizm@.br; José Guilherme Chaui- Berlinck* - jgcb@usp.br *Corresponding author Published: 5 February 2002 Received: 21 August 2001 Accepted: 5 February 2002 BMC Physiology 2002, 2:3 This article is available from: /1472-6793/2/3 © 2002 Iadocicco et al; licensee BioMed Central Ltd. Verbatim copying and redistribution of this article are permitted in any medium for any purpose, provided this notice is preserved along with the articles original URL. Abstract Background: Blood leukocytes constitute two interchangeable sub-populations, the marginated and circulating pools. These two sub-compartments are found in normal conditions and are potentially affected by non-normal situations, either pathological or physiological. The dynamics between the compartments is governed by rate constants of margination (M) and return to circulation (R). Therefore, estimates of M and R may pr