acetylcholinesterase-inhibiting activity of salicylanilide n-alkylcarbamates and their molecular dockingacetylcholinesterase-inhibiting活性的n -水杨酰苯胺n-alkylcarbamates及其分子对接.pdfVIP

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acetylcholinesterase-inhibiting activity of salicylanilide n-alkylcarbamates and their molecular dockingacetylcholinesterase-inhibiting活性的n -水杨酰苯胺n-alkylcarbamates及其分子对接.pdf

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acetylcholinesterase-inhibiting activity of salicylanilide n-alkylcarbamates and their molecular dockingacetylcholinesterase-inhibiting活性的n -水杨酰苯胺n-alkylcarbamates及其分子对接

Molecules 2012, 17, 10142-10158; doi:10.3390/molecules170910142 OPEN ACCESS molecules ISSN 1420-3049 /molecules Article Acetylcholinesterase-Inhibiting Activity of Salicylanilide N-Alkylcarbamates and Their Molecular Docking Ales Imramovsky 1,*, Sarka Stepankova 2, Jan Vanco 3, Karel Pauk 1, Juana Monreal-Ferriz 4, Jarmila Vinsova 4 and Josef Jampilek 3,* 1 Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic 2 Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic 3 Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho 1/3, 612 42 Brno, Czech Republic 4 Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic * Authors to whom correspondence should be addressed; E-Mails: ales.imramovsky@upce.cz (A.I.); josef.jampilek@ (J.J.); Tel.: +420-466-037-739 (A.I.); Fax: +420-466-038-004 (A.I.); Tel.: +420-541-562-925 (J.J.); Fax: +420-541-240-607 (J.J.). Received: 30 July2012; in revised form: 1 August 2012 / Accepted: 10 August 2012 / Published: 24 August 2012 Abstract: A series of twenty-five novel salicylanilide N-alkylcarbamates were investigated as potential acetylcholinesterase inhibitors. The compounds were tested for their ability to inhibit acetylcholin