a synthesis of 6-(2,5-dimethoxy-4-(2-aminopropyl)phenyl)-hexylthiol. a ligand for conjugation with fluorescent cadmium selenidezinc sulfide coreshell nanocrystals and biological imaging合成6 -(2,5-dimethoxy-4 -(2-aminopropyl)苯基)-hexylthiol。.pdfVIP

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a synthesis of 6-(2,5-dimethoxy-4-(2-aminopropyl)phenyl)-hexylthiol. a ligand for conjugation with fluorescent cadmium selenidezinc sulfide coreshell nanocrystals and biological imaging合成6 -(2,5-dimethoxy-4 -(2-aminopropyl)苯基)-hexylthiol。.pdf

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a synthesis of 6-(2,5-dimethoxy-4-(2-aminopropyl)phenyl)-hexylthiol. a ligand for conjugation with fluorescent cadmium selenidezinc sulfide coreshell nanocrystals and biological imaging合成6 -(2,5-dimethoxy-4 -(2-aminopropyl)苯基)-hexylthiol。

Molecules 2002, 7, 777-790 molecules ISSN 1420-3049 A Synthesis of 6-(2,5-Dimethoxy-4-(2-aminopropyl)phenyl)- hexylthiol. A Ligand for Conjugation with Fluorescent Cadmium Selenide/Zinc Sulfide Core/Shell Nanocrystals and Biological Imaging. * Ian D. Tomlinson, Jesse L. Grey and Sandra J. Rosenthal The Department of Chemistry, Vanderbilt University, Station B, 351822, Nashville, Tennessee, 37235-1822, USA. Fax: (+1) 615 343 1234 * Author to whom correspondence should be addressed; e-mail: sjr@ Received 13 August 2002; in revised form: 27 November 2002 / Accepted: 27 November 2002 / Published: 30 November 2002 Abstract: The synthesis of 6-(2,5-dimethoxy-4-(2-aminopropyl)phenyl)hexylthiol, an agonist with a very high affinity for the 5HT2A serotonin receptor subtype is reported. This agonist was designed to be attached to highly fluorescent cadmium selenide/zinc sulfide core/shells via a thiol at the end of a linker arm. This conjugate has applications in biological assays and biological imaging. Keywords: Cadmium selenide / zinc sulfide / core/shells / 5HT2A / fluorescent imaging. Introduction When a narrow band gap semiconductor nanocrystal (or quantum dot) is coated with a shell of a wider band gap semiconductor, a new material, a core/shell nanocrystal, is produced. An example are CdSe/ZnS core/shell nanocrystals [1]. These core/shells have novel physical characteristics, one of the most important being size-tunable, narrow fluorescence emission bands. The fluorescence emission is a resul