a role for adenosine a1 receptors in gaba and nmda-receptor mediated modulation of dopamine release studies using fast cyclic voltammetry腺苷a1受体的作用在gaba和门冬氨酸受体介导多巴胺释放的调制研究使用快速循环伏安法.pdfVIP
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a role for adenosine a1 receptors in gaba and nmda-receptor mediated modulation of dopamine release studies using fast cyclic voltammetry腺苷a1受体的作用在gaba和门冬氨酸受体介导多巴胺释放的调制研究使用快速循环伏安法
Sensors 2008, 8, 5516-5534; DOI: 10.3390/s8095516
OPEN ACCESS
sensors
ISSN 1424-8220
/sensors
Article
A Role for Adenosine A1 Receptors in GABA and
NMDA-Receptor Mediated Modulation of Dopamine Release:
Studies Using Fast Cyclic Voltammetry
John J. O’Connor * and Carmel O’Neill
UCD School of Biomolecular and Biomedical Science, UCD Conway Institute of Biomolecular
Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
* Author to whom correspondence should be addressed; E-mail: john.oconnor@ucd.ie
Received: 16 June 2008; in revised form: 1 September 2008 / Accepted: 2 September 2008 /
Published: 5 September 2008
Abstract: In the striatum many neurotransmitters including GABA, glutamate,
acetylcholine, dopamine, nitric oxide and adenosine interact to regulate synaptic
transmission. Dopamine release in the striatum is regulated by a number of pre- and post-
synaptic receptors including adenosine. We have recently shown using isolated rat striatal
slices, and the technique of fast cyclic voltammetry, that adenosine A receptor-mediated
1
inhibition of dopamine release is modulated by dopamine D receptors. In the present study
1
we have investigated the influence of NMDA and GABA receptor activation on the
modulation of electrical
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