a population-based study of anxiety as a precursor for depression in childhood and adolescence以人群为基础的研究在童年和青春期焦虑作为抑郁症的前兆.pdfVIP

BMC Psychiatry BioMed Central Research article Open Access A population-based study of anxiety as a precursor for depression in childhood and adolescence 1,2 1 1 Frances Rice* , Marianne BM van den Bree and Anita Thapar Address: 1Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK and 2School of Psychology, Cardiff University, Cardiff, UK Email: Frances Rice* - ricef@cardiff.ac.uk; Marianne BM van den Bree - vandenbreemb@cardiff.ac.uk; Anita Thapar - thapar@cardiff.ac.uk * Corresponding author Published: 13 December 2004 Received: 21 July 2004 Accepted: 13 December 2004 BMC Psychiatry 2004, 4:43 doi:10.1186/1471-244X-4-43 This article is available from: /1471-244X/4/43 © 2004 Rice et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Anxietydepressionchildtwinlongitudinalgenetic Background: Anxiety and depression co-occur in children and adolescents with anxiety commonly preceding depression. Although there is some evidence to suggest that the association between early anxiety and later depression is explained by a shared genetic aetiology, the contribution of environmental facto