大基因组数据与生物信息学英文及翻译教案.docxVIP

Big Genomic Data in Bioinformatics CloudAbstractThe achievement of Human Genome project has led to the proliferation of genomic sequencing data. This alongwith the next generation sequencing has helped to reduce the cost of sequencing, which has further increased thedemand of analysis of this large genomic data. This data set and its processing has aided medical researches.Thus, we require expertise to deal with biological big data. The concept of cloud computing and big datatechnologies such as the Apache Hadoop project, are hereby needed to store, handle and analyse this data. Because, these technologies provide distributed and parallelized data processing and are efficient to analyse evenpetabyte (PB) scale data sets. However, there are some demerits too which may include need of larger time totransfer data and lesser network bandwidth, majorly.人类基因组计划的实现导致基因组测序数据的增殖。这与下一代测序一起有助于降低测序的成本，这进一步增加了对这种大基因组数据的分析的需求。该数据集及其处理有助于医学研究。因此，我们需要专门知识来处理生物大数据。因此，需要云计算和大数据技术（例如Apache Hadoop项目）的概念来存储，处理和分析这些数据。因为，这些技术提供分布式和并行化的数据处理，并且能够有效地分析甚至PB级的数据集。然而，也有一些缺点，可能包括需要更大的时间来传输数据和更小的网络带宽，主要。Introduction The introduction of next generation sequencing has given unrivalledlevels of sequence data. So, the modern biology is incurring challengesin the field of data management and analysis. A single humans DNAcomprises around 3 billion base pairs (bp) representing approximately100 gigabytes (GB) of data. Bioinformatics is encountering difficulty instorage and analysis of such data. Moores Law infers that computersdouble in speed and half in size every 18 months. And reports say thatthe biological data will accumulate at even faster pace [1]. Sequencinga human genome has decreased in cost from $1 million in 2007 to $1thousand in 2012. With this falling cost of sequencing and after thecompletion of the Human Genome project in 2003, inundate ofbiological sequence data was generated. Sequencing and cataloguinggenetic information has increased