on oxidative stress and diabetic retinopathy（氧化应激与糖尿病性视网膜病变）.docVIP

On oxidative stress and diabetic retinopathy [Abstract] Diabetic retinopathy (diabetic retinopathy, DR is the most common microvascular complications of diabetes, blindness in adults in developed countries and many diabetes-induced metabolic abnormalities are affected by increased oxidative stress, but its exact The mechanism is still not very clear. In this paper, the role of oxidative stress on the impact of DR for a review. [Keywords:] diabetic retinopathy polyol pathway of oxidative stress glycation end products of protein kinase C hexosamine synthesis pathway of vascular endothelial growth factor Diabetic retinopathy (diabetic retinopathy, DR) is the most common microvascular complications of diabetes, which is leading to adult-acquired blindness in developed countries the main reason the long-term complications of diabetes cause high blood sugar is the root cause of High blood sugar can cause activity oxygen (reactive oxygen species, ROS over-production, the number of tissue oxidative stress. Oxidative stress also activates other harmful for the development of DR metabolic pathways, eventually leading to diabetes complications. An oxidative stress ROS mainly produced by the mitochondrial electron transport chain, but can also by the cytochrome P450, NAD (PH oxidase produces nitric oxide synthase [1]. ROS’s main role is to maintain normal cell function, however, ROS generation and degradation it can lead to an imbalance of molecular oxygen or elevated levels of ROS, which increased oxidative stress levels, cells can not resist oxidative stress is too much of ROS generated by cell disease, its occurrence on behalf of the generation of excess ROS and / or Clear mechanism damage. Diabetes can lead to increased oxidative stress, and increased oxidative stress and can contribute to diabetic neuropathy, nephropathy, myocardial damage and retinopathy. Oxidative stress and DR 2 Retina is rich in polyunsaturated fatty acids, and com